Your safety is our first priority. Learn more about key medication details, side effects, and other important information about your treatment.

Important Safety Information

Anastrozole is a prescription medication that belongs to a class of drugs known as aromatase inhibitors. It is FDA-approved for the treatment of hormone receptor-positive breast cancer in postmenopausal women. Anastrozole is also used off-label in men to manage estrogen levels, often in conjunction with testosterone replacement therapy (TRT) to prevent estrogen-related side effects such as gynecomastia (male breast enlargement).

Anastrozole should only be used under the supervision of a qualified healthcare provider.

Do not take Anastrozole if you:

• Are pregnant or may become pregnant. Anastrozole can harm an unborn baby.
• Are breastfeeding.
• Are allergic to anastrozole or any of its inactive ingredients.
• Have not gone through menopause (in female patients), unless directed by your physician.

Warnings and Precautions:

• Anastrozole can cause a decrease in bone mineral density, increasing the risk of osteoporosis and fractures. Bone density should be monitored during long-term use.
• May raise cholesterol levels—monitor your lipid profile regularly if using long term.
• Use with caution in patients with liver disease or a history of blood clots.
• Not approved for use in children or for performance enhancement.
• Inform all healthcare providers and dentists that you are taking anastrozole before any procedures or surgeries.

Possible Side Effects

Contact your healthcare provider immediately if you experience any of the following while taking Anastrozole:

• Signs of a blood clot (e.g., swelling, redness, warmth in the leg; sudden chest pain or shortness of breath)
• Severe bone pain or frequent fractures
• Unusual fatigue, yellowing of the eyes or skin (signs of liver problems)
• Blurred vision, dizziness, or fainting

Before Taking Anastrozole, Tell Your Healthcare Provider If You:

• Have or had liver or kidney disease
• Have osteoporosis or low bone mineral density
• Have a history of cardiovascular disease or high cholesterol
• Are currently taking hormone therapies, including estrogen or testosterone
• Are using any medications that affect bone health or cholesterol

Important Notes:

• Anastrozole is taken by mouth, typically once daily, with or without food.
• It may take several weeks to notice changes in hormone levels or symptoms.
• Routine blood tests may be required to monitor hormone levels, liver function, and cholesterol.
• Keep this medication out of the reach of children and store it at room temperature away from moisture and heat.

Drug Interactions

Tell your doctor about all medications and supplements you take. Anastrozole may interact with:

• Estrogen-containing products (e.g., hormone replacement therapy, birth control)
• Other hormone therapies, including tamoxifen
• Medications that affect bone density or cholesterol

Common Side Effects Include:

• Hot flashes
• Joint or muscle pain
• Fatigue or weakness
• Headache
• Nausea
• Mild bone thinning
• Mood changes or mild depression

If you experience any side effects or have concerns about your treatment with Anastrozole, contact your healthcare provider immediately.