Your safety is our first priority. Learn more about key medication details, side effects, and other important information about your treatment.

Important Safety Information

Estradiol Vaginal Cream is a prescription medication used to treat symptoms of vulvar and vaginal atrophy due to menopause, such as dryness, burning, itching, and painful intercourse. It contains estrogen, a female hormone that helps maintain vaginal tissue health.

Estradiol should only be used under the supervision of a licensed healthcare provider.

Do not use Estradiol Vaginal Cream if you:

• Are pregnant or may become pregnant
• Are breastfeeding
• Have a history of estrogen- or progesterone-sensitive cancer (e.g., breast or uterine cancer)
• Have unexplained vaginal bleeding
• Have a history of blood clots, stroke, heart attack, or liver disease
• Are allergic to estradiol or any component of the cream

Warnings and Precautions:

• Use the lowest effective dose for the shortest duration consistent with treatment goals.
• Long-term use of estrogen products may increase the risk of endometrial cancer, stroke, blood clots, and dementia in women over 65.
• Women with a uterus should discuss whether they need to take a progestin in combination with estrogen to reduce the risk of endometrial cancer.
• Regular follow-up and gynecologic exams are recommended during treatment.

Possible Side Effects

Contact your healthcare provider if you experience any of the following:

• Vaginal bleeding, spotting, or discharge
• Pelvic pain or pressure
• Breast pain, swelling, or discharge
• Sudden severe headache, dizziness, or vision problems
• Shortness of breath, chest pain, or leg swelling

Common Side Effects May Include:

• Headache
• Breast tenderness
• Nausea
• Vaginal irritation or discharge
• Abdominal cramps or bloating

Before Using Estradiol Vaginal Cream, Tell Your Healthcare Provider If You:

• Have a history of breast, uterine, or ovarian cancer
• Have liver, kidney, thyroid, or gallbladder disease
• Have high blood pressure, diabetes, or high cholesterol
• Smoke or use tobacco products

Drug Interactions

Tell your healthcare provider about all medications and supplements you are taking, including:

• Other hormone therapies
• Thyroid medications
• Blood thinners (e.g., warfarin)
• Seizure medications

Administration & Storage:

• Use exactly as prescribed, typically applied directly into the vagina using the applicator provided.
• Do not use more or less than directed.
• Store at room temperature away from moisture and heat. Keep out of reach of children.

If you experience side effects or have any questions about your treatment, contact your healthcare provider for medical advice.