Your safety is our first priority. Learn more about key medication details, side effects, and other important information about your treatment.

Important Safety Information

Bupropion is a prescription medication used to treat depression, seasonal affective disorder (SAD), and to help people stop smoking (smoking cessation). It may be marketed under various brand names such as Wellbutrin® or Zyban®.

Bupropion should only be used under the supervision of a licensed healthcare provider.

Do not take Bupropion if you:

• Have a seizure disorder or a history of seizures
• Have an eating disorder such as anorexia nervosa or bulimia
• Are taking or have recently taken monoamine oxidase inhibitors (MAOIs)
• Are abruptly stopping alcohol, benzodiazepines, barbiturates, or anti-seizure medications
• Are allergic to bupropion or any of its ingredients

Warnings and Precautions:

• Bupropion may increase the risk of seizures, especially at higher doses.
• There is a risk of suicidal thoughts or behaviors, particularly in young adults and adolescents. Monitor mood and behavior closely, especially when starting treatment or changing the dose.
• Use caution if you have high blood pressure, liver or kidney problems, or a history of mental health conditions such as bipolar disorder.
• Do not exceed the prescribed dose, and do not take more than one bupropion-containing product at a time.

Possible Side Effects

Seek immediate medical attention if you experience:

• Seizures
• Chest pain or irregular heartbeat
• Severe headache or vision changes
• Confusion, hallucinations, or suicidal thoughts
• Rash, itching, or swelling of the face, tongue, or throat

Common Side Effects May Include:

• Dry mouth
• Insomnia or trouble sleeping
• Dizziness
• Weight loss
• Headache
• Anxiety or agitation
• Sweating

Before Taking Bupropion, Tell Your Healthcare Provider If You:

• Have a history of seizures or head trauma
• Drink alcohol regularly
• Have liver or kidney disease
• Have a history of mental health issues, including bipolar disorder or suicidal thoughts
• Are pregnant, planning to become pregnant, or breastfeeding

Drug Interactions

Tell your provider about all the medications and supplements you take, including:

• Other antidepressants
• Antipsychotic medications
• Seizure medications
• MAO inhibitors
• Over-the-counter supplements and herbal remedies (e.g., St. John’s Wort)

Administration & Storage:

• Take exactly as prescribed, with or without food.
• Swallow tablets whole—do not crush, chew, or split.
• Store at room temperature, away from heat and moisture. Keep out of reach of children.

If you experience side effects or have questions about your medication, contact your healthcare provider immediately. Never stop Bupropion suddenly without medical advice.