Your safety is our first priority. Learn more about key medication details, side effects, and other important information about your treatment.

Important Safety Information

Enclomiphene is a selective estrogen receptor modulator (SERM) used off-label to treat men with secondary hypogonadism (low testosterone caused by inadequate signaling from the brain). It helps stimulate the body’s own natural testosterone production while preserving fertility, unlike traditional testosterone replacement therapy (TRT).

Enclomiphene is not FDA-approved but is prescribed off-label under the supervision of a licensed healthcare provider.

Do not take Enclomiphene if you:

• Are allergic to enclomiphene, clomiphene, or any other ingredients in the medication.
• Have liver disease or a history of liver dysfunction.
• Have a history of hormone-sensitive cancers such as prostate or testicular cancer.
• Have unexplained vision problems or visual disturbances.

Warnings and Precautions:

• Enclomiphene may cause vision changes. Stop taking the medication and notify your doctor if you experience blurred vision, flashes of light, or other visual disturbances.
• May increase testosterone and estradiol levels; routine blood work is required to monitor hormone levels and ensure safety.
• Use with caution in individuals with a history of blood clots or at risk for thromboembolic events.
• Not approved for use in women, children, or adolescents.

Possible Side Effects

Call your healthcare provider if you experience any of the following side effects while taking Enclomiphene:

• Vision disturbances (blurriness, floaters, flashes of light)
• Mood swings, irritability, or anxiety
• Headache or dizziness
• Nausea or abdominal discomfort
• Breast tenderness or enlargement
• Acne or oily skin
• Hot flashes or sweating

Before Taking Enclomiphene, Tell Your Healthcare Provider If You:

• Have a history of liver disease or abnormal liver function tests
• Have ever had blood clots, deep vein thrombosis (DVT), or pulmonary embolism (PE)
• Have high cholesterol or other cardiovascular risk factors
• Are taking other hormone-altering medications or fertility treatments

Important Notes:

• Enclomiphene is taken orally, usually once daily, as directed by your healthcare provider.
• It is typically prescribed as an alternative to testosterone injections or gels, especially for men seeking to maintain fertility.
• Routine blood tests are necessary to monitor hormone levels, liver function, and other parameters during treatment.
• This medication is not intended for bodybuilding or performance enhancement.
• Keep out of reach of children and store in a cool, dry place.

Drug Interactions

Tell your doctor about all the medications and supplements you take. Enclomiphene may interact with:

• Other hormone therapies (e.g., testosterone, hCG)
• Medications that affect liver enzymes (e.g., antifungals, antibiotics)
• Anticoagulants (blood thinners)
• Selective estrogen receptor modulators (SERMs) or aromatase inhibitors (AIs)

Common Side Effects Include:

• Headache
• Mild nausea
• Hot flashes
• Mood changes
• Mild increase in estradiol

If you experience any concerning side effects or have questions about Enclomiphene, contact your healthcare provider immediately.