Your safety is our first priority. Learn more about key medication details, side effects, and other important information about your treatment.

Important Safety Information

Metformin ER (Extended Release) is a prescription medication used to manage blood sugar levels in individuals with type 2 diabetes. It belongs to a class of drugs called biguanides. Metformin works by helping your body respond better to insulin, decreasing the amount of sugar made by the liver, and improving absorption of sugar by muscles.

Metformin ER is not used to treat type 1 diabetes or diabetic ketoacidosis. It should be used under the supervision of a licensed healthcare provider.

Do Not Take Metformin ER If You:

• Are allergic to metformin or any of its ingredients
• Have severe kidney problems or significantly reduced kidney function
• Have a condition called metabolic acidosis (including diabetic ketoacidosis)
• Are scheduled for a procedure involving contrast dye (such as a CT scan), unless your provider advises it is safe

Warnings and Precautions:

• Lactic Acidosis: A rare but serious condition caused by a buildup of lactic acid in the blood. Symptoms include unusual tiredness, muscle pain, trouble breathing, stomach discomfort, slow heart rate, or feeling cold. Seek immediate medical help if you experience these symptoms.
• Kidney Function: Kidney health must be monitored before and during treatment. The risk of lactic acidosis increases if your kidneys are not working properly.
• Liver Problems: Use caution if you have liver disease, as it may increase the risk of side effects.
• Alcohol Use: Avoid excessive alcohol while taking metformin, as it increases the risk of lactic acidosis.

Possible Side Effects

Contact your healthcare provider immediately if you experience:

• Severe stomach pain
• Trouble breathing or shortness of breath
• Feeling unusually cold or weak
• Slow or irregular heartbeat
• Unusual muscle pain

Common Side Effects May Include:

• Diarrhea
• Nausea or vomiting
• Stomach discomfort
• Gas or bloating
• Headache
• Loss of appetite
• Metallic taste in mouth

Before Taking Metformin ER, Tell Your Healthcare Provider If You:

• Have kidney or liver disease
• Drink alcohol frequently
• Have heart problems
• Are over 65 years old
• Are pregnant, trying to become pregnant, or breastfeeding
• Are planning a surgery or imaging procedure with contrast dye

Drug & Food Interactions

Inform your healthcare provider about all medications and supplements you are taking, especially:

• Diuretics (water pills)
• Blood pressure or heart medications (such as beta blockers)
• Insulin or other diabetes medications
• Thyroid or hormone medications
• Herbal supplements

Administration & Storage:

• Take Metformin ER exactly as prescribed, usually once daily with the evening meal.
• Swallow tablets whole — do not crush, chew, or split.
• You may see a soft shell of the tablet in your stool. This is normal and expected.
• Store at room temperature, away from moisture and heat.
• Keep out of reach of children and pets.

Do not stop or adjust your dosage without speaking to your healthcare provider. Regular lab tests, including kidney function, may be required during treatment.

If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double up on doses.