Your safety is our first priority. Learn more about key medication details, side effects, and other important information about your treatment.

Important Safety Information

Progesterone is a hormone naturally produced by the body. Prescription progesterone capsules are used to treat a variety of hormone-related conditions, including hormone replacement therapy (HRT) in postmenopausal women, menstrual irregularities, and to support pregnancy in certain cases. These capsules may come in 100mg, 150mg, or 200mg strengths depending on your specific treatment plan.

Progesterone should only be used under the guidance of a licensed healthcare provider.

Do not take Progesterone if you:

• Are allergic to progesterone, peanuts (some capsules may contain peanut oil), or any ingredients in the capsule.
• Have a history of blood clots (deep vein thrombosis or pulmonary embolism).
• Have liver disease or impaired liver function.
• Have unexplained vaginal bleeding.
• Have had certain cancers, especially breast or uterine cancer, unless prescribed as part of treatment by your provider.
• Are pregnant (unless progesterone is specifically prescribed to support pregnancy).

Warnings and Precautions:

• Progesterone may increase the risk of blood clots, stroke, heart attack, or breast cancer, especially when used long-term in combination with estrogen.
• May cause drowsiness or dizziness—do not drive or operate heavy machinery until you know how it affects you.
• Should be used with caution in people with a history of depression, seizures, asthma, migraines, or cardiovascular disease.
• Inform your doctor if you have diabetes or kidney problems before starting progesterone.

Possible Side Effects

Contact your healthcare provider if you experience any of the following:

• Chest pain, shortness of breath, or leg swelling (possible blood clot)
• Severe headache, vision problems, or speech difficulties (possible stroke)
• Unusual vaginal bleeding or discharge
• Yellowing of the skin or eyes (signs of liver issues)
• Mood changes, including depression or anxiety

Common Side Effects Include:

• Drowsiness or dizziness
• Breast tenderness
• Bloating or abdominal cramps
• Headache
• Fatigue
• Spotting or changes in menstrual bleeding

Before Taking Progesterone, Tell Your Healthcare Provider If You:

• Are pregnant or planning to become pregnant
• Are breastfeeding
• Have a history of hormone-sensitive conditions such as breast or uterine cancer
• Take any medications, including estrogen therapy or herbal supplements

Drug Interactions

Tell your provider about all medicines and supplements you take. Progesterone may interact with:

• Other hormone therapies (e.g., estrogen)
• Anticonvulsants (used to treat seizures)
• Antibiotics or antifungal medications
• Blood thinners
• Herbal supplements, especially St. John’s Wort

Administration & Storage:

• Take this medication exactly as prescribed—usually at bedtime if it causes drowsiness.
• Swallow the capsule whole with a full glass of water. Do not crush or chew.
• Store at room temperature away from moisture and heat. Keep out of reach of children.

If you have any concerns or experience any side effects while taking progesterone capsules, consult your healthcare provider promptly.