Your safety is our first priority. Learn more about key medication details, side effects, and other important information about your treatment.

Important Safety Information

Spironolactone is a prescription medication used to treat high blood pressure, heart failure, hyperaldosteronism (a condition where the body produces too much aldosterone), low potassium levels, and edema (fluid retention) caused by liver, kidney, or heart conditions. It belongs to a class of medications called aldosterone receptor antagonists or potassium-sparing diuretics. It works by helping the kidneys remove excess water and sodium while conserving potassium.

Spironolactone should only be used under the supervision of a licensed healthcare provider.

Do Not Take Spironolactone If You:

• Are allergic to spironolactone or any of its ingredients
• Have Addison’s disease or other conditions that cause high potassium levels (hyperkalemia)
• Have severe kidney disease or are unable to urinate
• Are taking eplerenone or potassium supplements without medical supervision

Warnings and Precautions:

• Hyperkalemia: Spironolactone may cause high potassium levels, which can be serious or life-threatening. Your doctor may monitor your potassium and kidney function regularly.
• Hormonal Side Effects: May cause breast enlargement or tenderness, menstrual irregularities, or sexual side effects.
• Liver or Kidney Disease: Use with caution if you have liver or kidney problems. Dose adjustments may be needed.
• Drowsiness or Dizziness: This medication may impair your ability to drive or operate machinery, especially when starting or adjusting the dose.
• Alcohol Use: Drinking alcohol may increase the risk of dizziness, lightheadedness, or fainting.

Possible Side Effects

Seek immediate medical attention if you experience:

• Severe muscle weakness or cramping
• Irregular heartbeat or chest pain
• Severe dizziness or fainting
• Swelling of the face, lips, tongue, or throat
• Confusion or difficulty breathing
• Yellowing of the skin or eyes (jaundice)

Common Side Effects May Include:

• Nausea or vomiting
• Headache
• Dizziness
• Breast tenderness or enlargement
• Irregular menstrual periods
• Fatigue or drowsiness

Before Taking Spironolactone, Tell Your Healthcare Provider If You:

• Have kidney or liver problems
• Have Addison’s disease or a history of high potassium levels
• Are pregnant, planning to become pregnant, or breastfeeding
• Are taking any potassium supplements, salt substitutes, or diuretics
• Are scheduled for surgery or dental procedures

Drug & Food Interactions

Tell your doctor about all medications and supplements you are taking, especially:

• Potassium supplements or salt substitutes containing potassium
• ACE inhibitors or ARBs (e.g., lisinopril, losartan)
• NSAIDs (e.g., ibuprofen, naproxen)
• Digoxin, lithium, or other heart medications
• Other diuretics or blood pressure medications

Administration & Storage:

• Take spironolactone exactly as prescribed, at the same time each day.
• It can be taken with or without food, but take it the same way each time.
• If using the oral suspension (Carospir), shake well before each use.
• Do not switch between tablet and suspension forms unless directed by your doctor.
• Store at room temperature, away from moisture and heat.
• Keep out of reach of children and do not use expired medication.

Missed Dose:

If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double up.

Dietary Advice:

• Follow your healthcare provider’s dietary guidelines, especially regarding sodium and potassium intake.
• Avoid potassium-rich foods (e.g., bananas, oranges, spinach) or potassium-containing salt substitutes unless advised otherwise.

If you experience side effects or have concerns about your medication, contact your healthcare provider immediately. Do not stop taking spironolactone without medical supervision.